Mechanisms of spreading depolarization in vertebrate and insect central nervous systems

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Mechanisms of spreading depolarization in vertebrate and insect central nervous systems.

Spreading depolarization (SD) is generated in the central nervous systems of both vertebrates and invertebrates. SD manifests as a propagating wave of electrical depression caused by a massive redistribution of ions. Mammalian SD underlies a continuum of human pathologies from migraine to stroke damage, whereas insect SD is associated with environmental stress-induced neural shutdown. The gener...

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ژورنال

عنوان ژورنال: Journal of Neurophysiology

سال: 2016

ISSN: 0022-3077,1522-1598

DOI: 10.1152/jn.00352.2016